Expressive

rs10822153 - JMJD1C

Magnitude 2.2 · 2 studies on file

Reported associations

  • Using human genetics to understand the disease impacts of testosterone in men and women - Unknown journal (n.d.) · Unknown authors · PubMed 32042192

    ABSTRACT: Testosterone supplementation is commonly used for its effects on sexual function, bone health and body composition, yet its effects on disease outcomes are unknown. To better understand this, we identified genetic determinants of testosterone levels and related sex hormone traits in 425,097 UK Biobank study participants. Using 2,571 genome-wide significant associations, we demonstrate the genetic determinants of testosterone levels are substantially different between sexes, and that genetically higher testosterone is harmful for metabolic diseases in women but beneficial in men. For example, a genetically determined 1-standard deviation higher testosterone increases the risks of Type 2 diabetes (T2D) (OR=1.37 [1.22-1.53]) and polycystic ovary syndrome (OR=1.51 [1.33-1.72]) in

  • GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids - Unknown journal (n.d.) · Unknown authors · PubMed 40545721

    ABSTRACT: Summary Previous genome-wide association studies (GWAS) have identified genetic loci associated with the circulating levels of fatty acids (FAs), but the biological mechanisms of these genetic associations remain largely unexplored. Here, we conducted GWAS to identify additional genetic loci for 19 circulating FA traits in UK Biobank participants of European ancestry (n = 239,268) and five other ancestries (n = 508-4,663). We leveraged the GWAS findings to characterize genetic correlations and colocalized regions among FAs, explore sex differences, examine FA loci influenced by lipoprotein metabolism, and apply statistical fine-mapping to pinpoint putative causal variants. We integrated GWAS signals with multi-omics quantitative trait loci (QTL) to reveal intermediate molecular

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • excess omega-6 seed oils High

    The A risk allele is associated with lower omega-3 to omega-6 ratio; limiting omega-6 oils helps maintain a more favorable ratio.

    Minimize vegetable oils (soybean, corn, sunflower); prefer olive oil, avocado oil, or coconut oil

  • omega-3 rich foods High

    The A risk allele is associated with lower omega-3 to total fatty acid percentage and reduced DHA levels, indicating genetic predisposition to lower omega-3 bioavailability.

    2-3 servings per week of fatty fish (salmon, sardines, mackerel) or equivalent algae-based sources

Discuss with your doctor

  • SHBG level assessment for hormonal optimization High

    The A risk allele is associated with elevated sex hormone-binding globulin levels, affecting bioavailable sex hormone concentrations.

Supplements

  • omega-3 fatty acid supplement High

    Genetic predisposition to lower circulating omega-3 levels may warrant supplementation to optimize cardiovascular health.

    1000-2000 mg combined EPA/DHA daily, discuss specific dosing and source with healthcare provider