Expressive

rs10820969 - CENPP

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827

    ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • serum uric acid levels Moderate

    The C allele at rs10820969 is associated with higher uric acid levels, which increases gout and kidney disease risk.

    Check every 1-2 years; target serum uric acid <6 mg/dL

Diet

  • high-fructose beverages and excess alcohol Moderate

    Both fructose and alcohol increase uric acid production; avoiding them helps lower levels in genetic risk carriers.

    Avoid sugar-sweetened beverages; limit alcohol to <2 drinks per day

  • high-purine foods like red meat and organ meats Moderate

    Purines are metabolized to uric acid; avoiding high-purine foods lowers uric acid in genetically predisposed individuals.

    Limit red meat to 2-3 times per week or less; avoid organ meats

Lifestyle

  • adequate water intake for uric acid excretion Moderate

    Adequate hydration increases kidney clearance of uric acid, helping lower serum levels.

    Drink 2-3 liters of water daily