rs10820254 - LINC00587 - CYLC2

Magnitude 2.2 · 1 study on file

Reported associations

• Two‐stage genome‐wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk - Unknown journal (n.d.) · Unknown authors · PubMed 33393196

  [INTRO] Chronic rhinosinusitis (CRS) is a prevalent inflammatory disease that results in over $10 billion in health‐care costs annually in the United States. CRS (and its most severe form, nasal polyposis [NP]) overlaps clinically with asthma and aspirin‐exacerbated respiratory disease (AERD). Despite having an enormous public health impact, the underlying molecular mechanisms of CRS remain unknown. [INTRO] That CRS has a genetic component is suggested by familial aggregation and co‐occurrence with both monogenic (eg, cystic fibrosis, primary ciliary dyskinesia) and complex (eg, asthma, allergic rhinitis) genetic disorders. Recently, Kristjansson et al reported their large meta‐analysis of genome‐wide association studies (GWAS) of CRS (n = 5608 cases) and NP (n = 4366 cases) fro

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