Expressive

rs10819613 - NCS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • sleep assessment and management strategies Moderate

    rs10819613 T allele is associated with increased insomnia risk

    Discuss genetic predisposition and consider evaluation for sleep disorders; explore behavioral and treatment options

Lifestyle

  • optimize sleep hygiene practices Moderate

    rs10819613 T allele is associated with increased insomnia risk; behavioral sleep optimization may help mitigate predisposition

    Consistent sleep schedule, dark and cool bedroom environment, avoid screens 1-2 hours before bed

Screening

  • sleep quality and sleep duration Moderate

    rs10819613 T allele is associated with increased insomnia risk; monitoring helps detect problems early

    Track sleep quality and duration weekly; discuss persistent issues with healthcare provider