rs10815621 - KANK1 - DMRT1

Magnitude 2.2 · 1 study on file

Reported associations

• Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. - Journal of gastroenterology and hepatology (2018) · Naito T, Yokoyama N, Kakuta Y, Ueno K, Kawai Y, Onodera M, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Endo K, Nagasaki M, Masamune A, Kinouchi Y, Shimosegawa T · PubMed 29603369

  Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce. Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Genotyping was performed using a population-optimized genotyping array (Japonica array ). After quality control, the genotype data of 4 384 682 single-nucleotide polymorphisms (SNPs) from 254 patients with IBD were used for GWAS. Body mass index, age, and disease duration were independently associated with the BMD of the femoral neck (P = 1.41

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