rs10813080 - LINGO2 - ME2P1
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo - Unknown journal (n.d.) · Unknown authors · PubMed 34620984
ABSTRACT: Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (Ncases = 48,072, Ncontrols = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide significant
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Vertigo risk and vestibular management strategy Moderate
Genetic predisposition warrants preventive discussion and management planning with healthcare provider.
Discuss at routine visit; review prevention strategies
Lifestyle
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Balance and vestibular training Moderate
Regular balance exercises improve proprioception and vestibular compensation for genetic predisposition.
3-4 sessions per week, 20-30 minutes each
Screening
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Balance and vestibular function screening Moderate
Genetic variant increases vertigo risk; baseline vestibular assessment enables early detection.
Baseline evaluation; annual follow-up if symptomatic