rs10811723 - DMRTA1 - LINC01239

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data - Unknown journal (n.d.) · Unknown authors · PubMed 31235808

  ABSTRACT: Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evi

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