rs1081073 - EBF1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic prediction of male pattern baldness - Unknown journal (n.d.) · Unknown authors · PubMed 28196072
ABSTRACT: Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0.78, sensitivity = 0.74, specificity = 0.69, PPV = 59%, NPV = 82%) those with no hair loss from those with severe hair loss. The results of this study might help identify those at greatest ris
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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hair loss treatment options Moderate
EBF1 variants increase androgenetic alopecia risk; early treatment initiation can slow disease progression.
Consult dermatologist about treatment options and their efficacy and side effects
Screening
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male-pattern baldness early detection Moderate
EBF1 rs1081073 A allele is strongly associated with increased androgenetic alopecia risk; early detection enables timely intervention.
Begin visual monitoring from age 20-25; consult dermatology if progressive hair loss noted