Expressive

rs10807610 - ESDP1 - CAP2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease - Unknown journal (n.d.) · Unknown authors · PubMed 33888516

    ABSTRACT: Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide association study (GWAS) meta-analysis to identify genetic risk factors for HEM to date. Design We conducted a GWAS meta-analysis of 218 920 patients with HEM and 725 213 controls of European ancestry. Using GWAS summary statistics, we performed multiple genetic correlation analyses between HEM and other traits as well as calculated HEM polygenic risk scores (PRS) and evaluated their translational potential in independent datasets. Using functional annotation of GWAS results, we identified HEM candidate genes, which differential expression and coexpression in H

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary fiber Moderate

    rs10807610 associates with hemorrhoidal disease; dietary fiber reduces constipation and straining, primary hemorrhoid risk factors

    20-30g daily, increase gradually to avoid bloating

  • fluid intake Moderate

    Hydration maintains soft stools and reduces straining, preventing hemorrhoid complications in genetically predisposed individuals

    8-10 cups water daily

Exercise

  • regular physical activity Moderate

    Regular exercise promotes intestinal motility and bowel regularity, reducing constipation risk in those with genetic predisposition to hemorrhoidal disease

    150 minutes moderate-intensity aerobic activity weekly

Lifestyle

  • prolonged straining during bowel movements Moderate

    Straining directly increases intra-abdominal pressure and hemorrhoid risk; prevention is critical for genetically susceptible individuals

    Maintain adequate fiber and fluid intake; do not delay or rush bowel movements