rs10805858 - MEF2C-AS1 - LINC02161
Magnitude 2.2 · 1 study on file
Reported associations
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 30643251
ABSTRACT: Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders. They are heritable and etiologically related behaviors that have been resistant to gene discovery efforts. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco an
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to smoking initiation High
The T allele of rs10805858 increases genetic susceptibility to smoking onset
Discuss with healthcare provider; develop prevention strategies based on individual risk factors
Lifestyle
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Smoking initiation or regular smoking High
Genetic variation confers elevated susceptibility to developing smoking habits and addiction
Implement evidence-based smoking avoidance strategies; seek support if nicotine exposure risk is high