rs1080490 - LINC02180 - CASC22

Magnitude 2.0 · 1 study on file

Reported associations

• Menarche-a journey into womanhood: age at menarche and health-related outcomes in East Asians. - Human reproduction (Oxford, England) (2024) · Chiou JS, Lin YJ, Chang CY, Liang WM, Liu TY, Yang JS, Chou CH, Lu HF, Chiu ML, Lin TH, Liao CC, Huang SM, Chou IC, Li TM, Huang PY, Chien TS, Chen HR, Tsai FJ · PubMed 38527428

  Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, and Mendelian randomization (MR), with additional findings indicating a causal effect of BMI and T2D on earlier AAM. Puberty timing is linked to adult disease risk, but research predominantly focuses on European populations, with limited studies in other groups. We performed an AAM genome-wide association study (GWAS) with 57 890 Han Taiwanese females and examined the association between AAM and 154 disease outcomes using the Taiwanese database. Additionally, we examined genetic correlations between AAM and 113 disea

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