rs10802047 - RNA5SP56 - PSMC1P12

Magnitude 2.2 · 1 study on file

Reported associations

• Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill - Unknown journal (n.d.) · Unknown authors · PubMed 24068947

  ABSTRACT: Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study meta-analysis for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)] (n = 728). The most strongly associated variant, rs7182874 (P = 8.68×10−9), is located in PCSK6, further supporting an association we previously reported. We also confirmed the specificity of this association in individuals with RD; the same locus was not associated with relative hand skill in a general population cohort (n = 2,666). As PCSK6 is known to regulate NODAL in the development of left/right (LR) asymmetry in mice, we d

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