rs10801923 - PTGFRN
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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refined carbohydrates and sugary drinks Moderate
Reduces postprandial glucose spikes and reduces insulin demand; critical for genetic diabetes predisposition
limit refined carbs to <10% daily calories; replace with whole grains, legumes, vegetables
Exercise
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regular aerobic exercise for metabolic health Moderate
Improves insulin sensitivity and glucose homeostasis; especially important given genetic diabetes risk
150 minutes moderate-intensity aerobic activity per week
Screening
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annual diabetes screening with HbA1c Moderate
G allele carriers show increased type 2 diabetes susceptibility in large GWAS; early detection enables preventive intervention
fasting glucose and HbA1c testing annually, more frequently if prediabetic