rs10801825 - BARHL2 - LINC02609
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic diversity fuels gene discovery for tobacco and alcohol use - Unknown journal (n.d.) · Unknown authors · PubMed 36477530
ABSTRACT: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury. These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries. Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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smoking initiation risk and targeted prevention High
Variant predisposes to earlier and more frequent smoking initiation; healthcare partnership can enhance prevention
Discuss genetic results and enhanced prevention strategies during adolescent healthcare visits
Lifestyle
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smoking initiation and cigarette use High
Variant strongly associated with increased smoking initiation risk in GWAS with 3.3M participants
Avoid cigarette use; if use occurs, pursue evidence-based cessation strategies
Screening
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smoking behavior in adolescence and early adulthood High
Variant associated with younger age of smoking initiation; proactive monitoring may enable early intervention
Screen for smoking behavior at annual healthcare visits starting at age 11-13 years