rs10801047 - LINC01680 - LINC02770

Magnitude 2.8 · 1 study on file

Reported associations

• Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn disease susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 17554261

  ABSTRACT: A genome-wide association scan in Crohn disease by the Wellcome Trust Case Control Consortium detected strong association at 6 novel loci. We tested 37 SNPs from these and other loci for association in an independent case control sample. Replication was obtained for the IRGM gene on chromosome 5q33.1 which induces autophagy (replication P = 6.6 × 10−4, combined P = 2.1 × 10−10), and for 9 other loci including NKX2-3 and gene deserts on chromosomes 1q and 5p13. FULL TEXT: [INTRO] Crohn disease (CD) is a common form of chronic inflammatory bowel disease. Established CD susceptibility genes NOD2 (CARD15), IL23R and ATG16L1​ showed strong evidence of association in the Wellcome Trust Case Control Consortium (WTCCC) genome-wide scan of 1748 CD cases and 2938 controls genotype

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