rs10800713 - KIF14

Magnitude 4.5 · 1 study on file

Reported associations

• Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants. - The journals of gerontology. Series A, Biological sciences and medical sciences (2017) · Adams HH, Verlinden VJ, Callisaya ML, van Duijn CM, Hofman A, Thomson R, Uitterlinden AG, Vernooij MW, van der Geest JN, Srikanth V, Ikram MA · PubMed 26219847

  Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam Study, a population-based cohort of unrelated elderly individuals. We assessed 30 gait parameters using an electronic walkway, which yielded seven independent gait domains after principal component analysis. Genotypes of participants were imputed to the 1,000 Genomes reference panel for generating genetic relationship matrices to estimate heritability of gait parameters, and for subsequent genome-wide association scans (GWASs) to identify specific variants. Gait domains with the highest age- and sex-adjusted heritability were Variability (h (2) = 61%), R

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