rs10800507 - LINC01681

Magnitude 2.2 · 1 study on file

Reported associations

• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 28416818

  ABSTRACT: Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, multi-racial meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 18,398 individuals with atrial fibrillation and 91,536 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,806 cases and 132,612 referents. We identified 12 novel genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remode

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