rs10800154 - TMCO1

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • glaucoma risk stratification from TMCO1 variant High

    rs10800154 is a validated GWAS locus for open-angle glaucoma with large effect size across diverse populations

Screening

  • glaucoma screening via eye exam High

    rs10800154 C allele associated with dramatically elevated open-angle glaucoma risk in GWAS meta-analysis of 612,895 individuals, effect size 0.154, p=1.0e-62

    comprehensive eye exam with intraocular pressure assessment; repeat annually per ophthalmology guidance