rs10798802 - LAPTM5 - LINC01778

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension - Unknown journal (n.d.) · Unknown authors · PubMed 36447229

  ABSTRACT: Background Compared with patients who require fewer antihypertensive agents, those with apparent treatment-resistant hypertension (aTRH) are at increased risk for cardiovascular and all-cause mortality, independent of blood pressure control. However, the etiopathogenesis of aTRH is still poorly elucidated. Methods We performed a genome-wide association study (GWAS) in first cohort including 586 aTRHs and 871 healthy controls. Next, expression quantitative trait locus (eQTL) analysis was used to identify genes that are regulated by single nucleotide polymorphisms (SNPs) derived from the GWAS. Then, we verified the genes obtained from the eQTL analysis in the validation cohort including 65 aTRHs, 96 hypertensives, and 100 healthy controls through gene expression profiling analysis

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