Expressive

rs10797551 - LINC01354

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome‐Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study - Unknown journal (n.d.) · Unknown authors · PubMed 32766472

    ABSTRACT: The global rise in fatty liver is a major public health problem. Thus, it is critical to identify both global and population‐specific genetic variants associated with liver fat. We conducted a genome‐wide association study (GWAS) of percent liver fat and nonalcoholic fatty liver disease (NAFLD) assessed by magnetic resonance imaging in 1,709 participants from the population‐based Multiethnic Cohort Adiposity Phenotype Study. Our participants comprised older adults of five U.S. racial/ethnic groups: African Americans (n = 277), Japanese Americans (n = 424), Latinos (n = 348), Native Hawaiians (n = 274), and European Americans (n = 386). The established missense risk variant rs738409 located in patatin‐like phospholipase domain containing 3 (PNPLA3) at 22q13 was c

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Metabolic markers and liver enzymes Moderate

    Variant confers NAFLD risk; longitudinal monitoring of transaminases, lipids, and glucose detects progression early

    Annual fasting lipid panel, glucose, liver enzymes (ALT, AST), and platelet count

Diet

  • Reduce refined carbohydrates and added sugars Moderate

    Simple sugars promote hepatic lipogenesis and worsen NAFLD; restriction benefits those with genetic predisposition

    Limit added sugars to <25g per day; choose whole grains over refined carbohydrates

Exercise

  • Regular aerobic exercise Moderate

    Exercise improves insulin sensitivity and reduces hepatic triglycerides, critical for NAFLD prevention in at-risk individuals

    150 minutes per week moderate-intensity aerobic exercise or 75 minutes vigorous

Lifestyle

  • Alcohol consumption Moderate

    Alcohol exacerbates NAFLD; carriers of this NAFLD-risk variant have elevated baseline disease risk

    Minimize or avoid; if any alcohol, limit to 1 drink/day maximum

  • Weight management if overweight Moderate

    Excess adipose tissue increases NAFLD risk; weight loss improves hepatic steatosis in susceptible carriers

    Target BMI 18.5-25; if overweight, aim for 5-10 percent weight loss over 3-6 months

Screening

  • Liver function tests and abdominal ultrasound Moderate

    rs10797551 variant is associated with 1.515-fold increased nonalcoholic fatty liver disease risk

    Annual liver function tests and ultrasound; increased frequency if metabolic syndrome present