Expressive

rs10793514 - LINC00841 - LINC03089

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778

    ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Annual lipid panel and blood pressure assessment Moderate

    Lipids and blood pressure are modifiable coronary artery disease risk factors requiring systematic monitoring in genetic risk carriers.

    Check lipids, blood pressure, and glucose annually; increase frequency if abnormalities detected

Diet

  • Mediterranean-style diet with limited saturated fat Moderate

    Plant-based nutrition and reduced saturated fat decrease coronary artery disease progression in genetic risk carriers.

    Prioritize whole grains, vegetables, fruits, fish; limit saturated fat to under 7% of daily calories

Exercise

  • Regular aerobic exercise Moderate

    Aerobic activity reduces coronary artery disease risk, with particular benefit for individuals carrying genetic risk alleles.

    Aim for 150 minutes moderate-intensity aerobic activity weekly, or 75 minutes vigorous intensity

Screening

  • Cardiovascular risk assessment at age 30 Moderate

    rs10793514 risk allele associates with elevated coronary artery disease risk, requiring earlier baseline assessment and risk stratification.

    Initial assessment with physician; repeat every 3-5 years or per clinician guidance