rs1079304 - LINC02743

Magnitude 2.2 · 1 study on file

Reported associations

• Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities - Unknown journal (n.d.) · Unknown authors · PubMed 32517579

  ABSTRACT: Background and Purpose Periventricular (PVWMH) and deep white matter hyperintensities (DWMH) are regional classifications of white matter hyperintensities (WMH) and reflect proposed differences in etiology. In the first study to date, we undertook genome-wide association analyses (GWAS) of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. Methods Participants were aged 45 years and older; free of stroke and dementia. We conducted GWAS of PVWMH and DWMH in 26,654 participants from CHARGE, ENIGMA, and the UK Biobank (UKB). Regional correlations were investigated using the GWAS-pairwise method. Cross-trait genetic correlations between PVWMH, DWMH, stroke, and dementia were estimated using LDSC. Results In the discovery and replication analysis, for P

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