Expressive

rs10792352 - ASRGL1 - SCGB1A1

Magnitude 2.2 · 1 study on file

Reported associations

  • An atlas of genetic influences on osteoporosis in humans and mice - Unknown journal (n.d.) · Unknown authors · PubMed 30598549

    ABSTRACT: Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound (eBMD) in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with eBMD, in ~1.2M individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds-ratio=58, p=10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice lacking target genes and found an increased abnormal skeletal phenotype frequency compared to 526

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate calcium intake Moderate

    Calcium is essential for bone mineralization; carriers with lower BMD benefit from optimized intake

    1000-1200 mg daily from dairy, fortified foods, or leafy greens

Exercise

  • weight-bearing exercise Moderate

    Mechanical loading stimulates osteoblast activity and bone formation, countering genetic predisposition to lower BMD

    30+ minutes of weight-bearing or resistance activity most days

Screening

  • bone mineral density measurement Moderate

    rs10792352 C allele carriers have genetically lower heel bone mineral density; measurement reveals skeletal status

Supplements

  • vitamin D supplementation Moderate

    Vitamin D is required for calcium absorption; deficiency exacerbates genetic tendency toward lower BMD

    Target 30-50 ng/mL serum 25-OH vitamin D; supplement if needed