rs1079235 - DTD1
Magnitude 2.2 · 1 study on file
Reported associations
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Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model - Unknown journal (n.d.) · Unknown authors · PubMed 38767906
ABSTRACT: Purpose The purpose of this study was to conduct a large-scale genome-wide association study (GWAS) and construct a polygenic risk score (PRS) for risk stratification in patients with dry eye disease (DED) using the Taiwan Biobank (TWB) databases. Methods This retrospective case-control study involved 40,112 subjects of Han Chinese ancestry, sourced from the publicly available TWB. Cases were patients with DED (n = 14,185), and controls were individuals without DED (n = 25,927). The patients with DED were further divided into 8072 young (<60 years old) and 6113 old participants (≥60 years old). Using PLINK (version 1.9) software, quality control was carried out, followed by logistic regression analysis with adjustments for sex, age, body mass index, depression, and manic episod
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic predisposition to dry eye disease with eye care provider Moderate
GWAS identifies rs1079235-T as conferring elevated DED risk; ophthalmologist awareness supports early intervention strategies.
Screening
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Dry eye disease monitoring and periodic assessment Moderate
rs1079235-T allele increases genetic risk for dry eye disease; early detection enables preventive intervention.
Annual eye examination with focus on dry eye assessment, or sooner if ocular dryness, irritation, or grittiness develops.