Expressive

rs1079204 - AAMP

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. - Journal of dental research (2013) · Zeng Z, Shaffer JR, Wang X, Feingold E, Weeks DE, Lee M, Cuenco KT, Wendell SK, Weyant RJ, Crout R, McNeil DW, Marazita ML · PubMed 23470693

    While genetics clearly influences dental caries risk, few caries genes have been discovered and validated. Recent studies have suggested differential genetic factors for primary dentition caries and permanent dentition caries, as well as for pit-and-fissure- (PF) and smooth- (SM) surface caries. We performed separate GWAS for caries in permanent-dentition PF surfaces (1,017 participants, adjusted for age, sex, and the presence of Streptococcus mutans) and SM surfaces (1,004 participants, adjusted for age, education group, and the presence of Streptococcus mutans) in self-reported whites (ages 14 to 56 yrs). Caries scores were derived based on visual assessment of each surface of each tooth; more than 1.2 million SNPs were either successfully genotyped or imputed and were tested for associa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • frequent consumption of sugary foods and acidic drinks Moderate

    Fermentable carbohydrates directly promote caries-causing bacterial growth; genetic susceptibility increases disease risk from dietary carbohydrates.

    Limit sugary snacks and drinks between meals; consume during meals only; rinse mouth after acidic foods

Lifestyle

  • enhanced mechanical plaque removal protocol Moderate

    Plaque biofilm control is primary cavity prevention mechanism; genetic risk for smooth-surface caries suggests heightened benefit from superior oral hygiene.

    Brush with fluoride toothpaste twice daily, 2 minutes each; daily floss; electric toothbrush may improve efficacy

Screening

  • professional dental examination frequency Moderate

    Increased genetic predisposition to caries warrants more frequent clinical surveillance for early lesion detection and intervention.

    Professional dental exam and cleaning every 6 months; annual X-ray screening or more frequently if indicated