Expressive

rs10790077 - CADM1

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic risk for hip osteoarthritis and prevention strategy Moderate

    Early awareness of genetic predisposition enables proactive risk management and surveillance planning

Exercise

  • Hip and core strengthening exercise program Moderate

    Strong hip and core muscles provide joint stability and proprioceptive feedback; may reduce osteoarthritis progression in genetically predisposed individuals

    2-3 sessions per week hip/core strengthening plus 150 minutes per week moderate aerobic activity

Lifestyle

  • Maintain lean body weight to reduce hip joint stress Moderate

    Excess weight increases mechanical loading on hip joints; genetic predisposition to osteoarthritis may amplify this joint damage risk

    Target and maintain BMI 18.5-24.9; consider working with nutritionist for personalized weight management plan

Screening

  • Hip osteoarthritis monitoring starting at younger age Moderate

    Variant rs10790077-T is associated with increased hip osteoarthritis risk in large GWAS study of 1.15 million individuals

    Discuss with physician about baseline hip imaging and periodic surveillance