rs10789418 - CCDC30
Magnitude 2.2 · 1 study on file
Reported associations
-
Novel Genetic Locus of Visceral Fat and Systemic Inflammation. - The Journal of clinical endocrinology and metabolism (2020) · Shin J, Syme C, Wang D, Richer L, Pike GB, Gaudet D, Paus T, Pausova Z · PubMed 30942860
Visceral fat (VF), more than fat elsewhere in the body [mostly subcutaneous fat (SF)], promotes systemic inflammation and related disease. The mechanisms of preferentially visceral accumulation of body fat are largely unknown. To identify genetic loci and mechanistic pathways of preferential accumulation of VF and associated low-grade systemic inflammation. Genome-wide association study (GWAS). Population-based cohort of 1586 adolescents (aged 12 to 19 years) and adults (aged 36 to 65 years). Abdominal VF and SF were measured with MRI, total body fat (TBF) was assessed with bioimpedance, and low-grade systemic inflammation was examined by serum C-reactive protein (CRP) measurement. This GWAS of preferential accumulation of VF identified a significant locus on chromosome 6 at rs803522 (P =
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Visceral fat screening and risk management Moderate
Genetic predisposition to visceral fat accumulation warrants personalized discussion of prevention and risk reduction approaches
Discuss visceral fat screening and risk management with doctor
Screening
-
Visceral fat assessment Moderate
rs10789418-T allele is associated with 0.294 SD increase in visceral fat (p=2e-6); periodic monitoring recommended for risk carriers
Visceral fat imaging by abdominal CT or DEXA scan every 2-3 years starting by age 40