rs10789347 - LINC02796 - KRT8P21
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Unknown journal (n.d.) · Unknown authors · PubMed 31719535
ABSTRACT: Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lip
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Optimize sleep duration Moderate
This variant affects triglyceride levels; the effect is amplified by short sleep duration, suggesting longer sleep may mitigate lipid dysregulation
Target 7-9 hours of sleep per night
Screening
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Triglyceride levels Moderate
This variant is associated with triglyceride levels in the context of sleep duration; monitoring enables early detection of lipid dysregulation
Check fasting triglycerides annually or per physician guidance