Expressive

rs10789097 - NFIA - TM2D1

Magnitude 2.2 · 1 study on file

Reported associations

  • Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32314116

    ABSTRACT: Summary Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we performed a bivariate GWAS in five discovery samples and replicated in two large-scale samples. We identified 2 novel loci at 2q37.1 and 6q26. Our findings provide insight into common genetic architecture underlying both traits. Introduction Bone mineral density (BMD) and bone size (BS) are two important factors that contribute to the development of osteoporosis and osteoporotic fracture. Both BMD and BS are highly heritable and they are genetically correlated. In this study, we aim to identify pleiotropic loci associated with BMD and BS. Methods We conducted a bivariate genome-wide association (GWA) analysis of hip BMD and hip BS in 6180 participants from 5 samples, followed by in sili

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary calcium from food sources Moderate

    rs10789097-G associates with lower hip BMD; adequate calcium supports bone formation, especially for carriers

    Aim for 1000-1200 mg daily from dairy, leafy greens, or fortified foods

Exercise

  • weight-bearing exercise Moderate

    Weight-bearing exercise stimulates bone formation; especially beneficial for carriers of rs10789097-G with lower BMD

    150 minutes moderate-intensity per week or 2-3 sessions per week of resistance training

Screening

  • baseline bone density screening Moderate

    rs10789097-G carriers have genetically lower hip BMD; early screening identifies individual fracture risk for intervention

    Discuss DXA screening timeline with healthcare provider; consider baseline earlier than standard age-based guidelines

Supplements

  • vitamin D supplementation Moderate

    Vitamin D is essential for calcium absorption; inadequate levels may further reduce BMD in carriers of rs10789097-G

    1000-2000 IU daily; consider testing 25-hydroxyvitamin D levels