rs10787486 - RNU7-165P - PPIAP39

Magnitude 4.5 · 1 study on file

Reported associations

• Genomeâwide analysis of genetic determinants of circulating factorÂVIIâactivating protease (FSAP) activity - Unknown journal (n.d.) · Unknown authors · PubMed 30070759

  ABSTRACT: Summary Essentials Knowledge of genetic regulators of plasma factor VII activating protease (FSAP) levels is limited. We performed a genomeâwide analysis of variants influencing FSAP activity in Scandinavian cohorts. We replicated an association for Marburgâ1 and identified an association for a HABP2 stop variant. We identified a novel locus near ADCY2 as a potential additional regulator of FSAP activity. Summary Background FactorÂVIIâactivating protease (FSAP) has roles in both coagulation and fibrinolysis. Recent data indicate its involvement in several other processes, such as vascular remodeling and inflammation. Plasma FSAP activity is highly variable among healthy individuals and, apart from the lowâfrequency missense variant MarburgâI (rs7080536) in the FSAPâencodin

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