rs10787287 - PDCD4
Magnitude 2.2 · 1 study on file
Reported associations
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Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925
ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular aerobic and resistance exercise Moderate
Improves insulin sensitivity and glucose tolerance; directly counteracts T2D genetic risk
150 minutes moderate aerobic activity weekly plus 2+ resistance training sessions weekly
Lifestyle
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Weight management for diabetes prevention Moderate
Maintains insulin sensitivity; critical mitigation for genetic T2D predisposition
Target BMI 18.5-24.9; if overweight, aim for 5-10% weight loss
Screening
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Type 2 diabetes risk assessment Moderate
rs10787287-C allele increases Type 2 diabetes risk per large GWAS; enhanced monitoring enables early detection
Annual fasting glucose and HbA1c testing; baseline screening if none in past 3 years