rs10786411 - LOXL4 - PYROXD2

Magnitude 2.0 · 1 study on file

Reported associations

• Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications - Unknown journal (n.d.) · Unknown authors · PubMed 34177598

  ABSTRACT: Objective: Resistance to anti-seizure medications (ASMs) presents a significant hurdle in the treatment of people with epilepsy. Genetic markers for resistance to individual ASMs could support clinicians to make better-informed choices for their patients. In this study, we aimed to elucidate whether the response to individual ASMs was associated with common genetic variation. Methods: A cohort of 3,649 individuals of European descent with epilepsy was deeply phenotyped and underwent single nucleotide polymorphism (SNP)-genotyping. We conducted genome-wide association analyses (GWASs) on responders to specific ASMs or groups of functionally related ASMs, using non-responders as controls. We performed a polygenic risk score (PRS) analyses based on risk variants for epilepsy and neu

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