Expressive

rs10783377 - DIP2B

Magnitude 2.2 · 1 study on file

Reported associations

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Limit dietary sodium intake Moderate

    This SNP is associated with elevated systolic blood pressure; sodium restriction is an evidence-based intervention for blood pressure control

    Target less than 2300 mg per day, ideally less than 2000 mg per day

Exercise

  • Aerobic exercise for blood pressure management Moderate

    This SNP is associated with elevated systolic blood pressure; aerobic exercise reduces pressure through improved endothelial function

    150 minutes per week moderate-intensity exercise spread across 3 or more days

Lifestyle

  • Maintain healthy body weight Moderate

    This SNP predisposes to elevated systolic blood pressure; weight management is a key modifiable risk factor for blood pressure control

    Aim for BMI 18.5-24.9 kg/m2 or consult physician for personalized target

Screening

  • Baseline and regular blood pressure monitoring Moderate

    Genetic variant associated with increased systolic blood pressure; regular monitoring enables early detection and management

    Establish baseline, then check at least annually or more frequently if elevated