rs10779704 - RERE
Magnitude 2.2 · 1 study on file
Reported associations
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Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis - Unknown journal (n.d.) · Unknown authors · PubMed 40164604
ABSTRACT: Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to atopic dermatitis genetic association studies are poised to boost power to detect genetic signal and identify loci contributing to atopic dermatitis risk. Here, we present a multi-ancestry GWAS meta-analysis of twelve atopic dermatitis cohorts from five ancestral populations totaling 56,146 cases and 602,280 controls. We report 101 genomic loci associated with atopic dermatitis, including 16 loci that have not been previously associated with atopic dermatitis or eczema. Fine-mapping, QTL colocalization, and cell-type enrichment analyses identified genes and cell types implicated in atopic dermatitis pathophysiology. Functional analys
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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atopic dermatitis genetic predisposition Moderate
RERE variant shows significant genome-wide association with atopic dermatitis susceptibility
Discuss genetic finding with dermatologist or primary care physician, especially if family history present
Screening
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atopic dermatitis symptoms Moderate
Genetic variant associates with increased atopic dermatitis risk in genome-wide study of 658,426 individuals
Watch for persistent itching, dryness, or rash; seek dermatology evaluation if symptoms develop