Expressive

rs10778496 - RFX4

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean diet or whole-food based diet Moderate

    Mediterranean diets and whole-food patterns reduce central adiposity and improve metabolic and cardiovascular health markers

    Emphasize vegetables, whole grains, legumes, fish, and healthy fats; limit refined carbohydrates

    • GWAS_CATALOG:34021172

Exercise

  • aerobic exercise targeting central adiposity Moderate

    Aerobic exercise preferentially reduces abdominal fat and central adiposity independent of overall weight loss

    150-300 minutes moderate-intensity aerobic exercise weekly

    • GWAS_CATALOG:34021172

Screening

  • waist-to-hip ratio and central adiposity Moderate

    Genetic variant significantly increases waist-to-hip ratio independent of BMI, warranting regular monitoring of central adiposity

    Measure waist circumference and calculate waist-to-hip ratio annually

    • GWAS_CATALOG:34021172