rs10774679 - OAS1 - OAS3

Magnitude 2.2 · 1 study on file

Reported associations

• A first update on mapping the human genetic architecture of COVID-19 - Unknown journal (n.d.) · Unknown authors · PubMed 35922517

  [INTRO] The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. [FIG] Overview of contributing studies in Host Genetics Initiative data freeze 6. [FIG] a, Geographical overview of the contributing studies to the C

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