rs10774621 - LINC02356
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia∗ - Unknown journal (n.d.) · Unknown authors · PubMed 38064665
ABSTRACT: Key Points PEAR1 and CBL variants demonstrate time-specific genetic influences on platelet count throughout the course of pregnancy. PEAR1 and TUBB1 variants play a major role in contributing to the genetic predisposition for GT and severe GT. Visual Abstract Abstract Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet count during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing of 100 186 Chinese pregnant individuals and conducted, to our knowledge, the hitherto largest-scale genome-wide association studies on platelet counts
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Gestational thrombocytopenia risk with obstetric provider Moderate
Carriers of the G risk allele have 17 percent increased relative risk for low platelet counts during pregnancy, potentially affecting anesthesia and delivery planning.
Inform provider at first obstetric visit; ensure monitoring plan and discuss anesthesia implications.
Screening
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Platelet count monitoring during pregnancy Moderate
G allele at rs10774621 is associated with increased risk of gestational thrombocytopenia, affecting approximately 30 percent of the population.
Baseline platelet count at first prenatal visit; repeat monthly or per obstetric provider guidance during pregnancy.