Expressive

rs10774610 - CCDC63

Magnitude 4.5 · 2 studies on file

Reported associations

  • Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. - Circulation journal : official journal of the Japanese Circulation Society (2011) · Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N · PubMed 21372407

    Normative alcohol use (or drinking behavior) influences the risk of cardiovascular disease in a multi-faceted manner. To identify susceptibility gene variants for drinking behavior, a 2-staged genome-wide association study was performed in a Japanese population. In the stage-1 scan, 733 cases and 729 controls were genotyped with 456,827 SNP markers. The associated loci without redundancy of linkage disequilibrium were further examined in the stage-2 general population panel comprising 2,794 drinkers (≥ once per week), 1,521 chance drinkers (< once per week), and 1,351 non-drinkers. Along with genome-wide exploration, we aimed to replicate the trait association of a candidate gene SNP previously reported (rs1229984 in ADH1B). A cluster of 12 SNPs on 12q24 were found to significantly (P<5

  • Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease - Unknown journal (n.d.) · Unknown authors · PubMed 30226566

    ABSTRACT: Early-onset cardiovascular and renal diseases have a strong genetic component. In the present study, exome-wide association studies (EWASs) were performed to identify genetic variants that confer susceptibility to early-onset myocardial infarction (MI), hypertension, or chronic kidney disease (CKD) in Japanese individuals. A total of 8,093 individuals aged ≤65 years was enrolled in the study. The EWASs for MI, hypertension, and CKD were performed in 6,926 subjects (1,152 cases, 5,774 controls), 8,080 subjects (3,444 cases, 4,636 controls), and 2,556 subjects (1,051 cases, 1,505 controls), respectively. Genotyping of single nucleotide polymorphisms (SNPs) was performed with Illumina Human Exome-12 DNA Analysis BeadChip or Infinium Exome-24 BeadChip arrays. The associations of al

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Serum uric acid levels Moderate

    rs10774610 is specifically associated with hyperuricemia; elevated uric acid increases gout risk and may worsen cardiovascular outcomes.

    Check serum uric acid annually; if elevated, discuss management with healthcare provider.

Diet

  • Limit purine-rich foods and sugary drinks Moderate

    rs10774610 is associated with hyperuricemia; reducing purines and fructose is first-line management for elevated uric acid.

    Reduce red meat, organ meats, high-purine fish; limit sugary beverages and alcohol.

Lifestyle

  • Alcohol consumption awareness and moderation Moderate

    rs10774610 is associated with drinking behavior and hyperuricemia; alcohol raises uric acid and cardiovascular disease risk.

    Monitor alcohol intake; limit to ≤2 drinks/day (men) or ≤1/day (women).

Screening

  • Cardiovascular risk assessment and monitoring Moderate

    CCDC63 rs10774610 is part of a locus associated with myocardial infarction susceptibility; genetic predisposition warrants earlier screening.

    Discuss cardiovascular risk stratification with healthcare provider; monitor blood pressure and lipids regularly.