rs10774547 - RPS27P25 - COX6A1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide screening for DNA variants associated with reading and language traits - Unknown journal (n.d.) · Unknown authors · PubMed 25065397

  ABSTRACT: Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading- and language-related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10-7 for each SNP), located respectively at the CCDC136/FLNC and RBFO

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