rs10771746 - IPO8
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours - Unknown journal (n.d.) · Unknown authors · PubMed 32317632
ABSTRACT: Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P < 1×10−8), respectively. High genetic correlations are observed between sedentary behaviours and neurological traits, including education and body mass index (BMI). Two-sample Mendelian randomization (MR) analysis estimates a causal effect between 1.5 hour increase in television watching and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular aerobic and resistance activity Moderate
rs10771746 carriers show genetic predisposition to increased leisure sedentary behavior with reduced IPO8 expression in brain reward and motivation centers
150 minutes weekly moderate-intensity aerobic activity plus 2x weekly resistance training
Lifestyle
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Leisure screen time and sedentary behavior Moderate
GWAS genome-wide significant association between rs10771746 and increased leisure television watching behavior
Track daily leisure screen time; establish target under 2 hours per day outside work obligations