rs10770607 - TCP1P3 - LINC02468

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic insights into ossification of the posterior longitudinal ligament of the spine - Unknown journal (n.d.) · Unknown authors · PubMed 37461309

  ABSTRACT: Ossification of the posterior longitudinal ligament of the spine (OPLL) is an intractable disease leading to severe neurological deficits. Its etiology and pathogenesis are primarily unknown. The relationship between OPLL and comorbidities, especially type 2 diabetes (T2D) and high body mass index (BMI), has been the focus of attention; however, no trait has been proven to have a causal relationship. We conducted a meta-analysis of genome-wide association studies (GWASs) using 22,016 Japanese individuals and identified 14 significant loci, 8 of which were previously unreported. We then conducted a gene-based association analysis and a transcriptome-wide Mendelian randomization approach and identified three candidate genes for each. Partitioning heritability enrichment analyses ob

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