Expressive

rs10770140 - TH - MIR4686

Magnitude 2.2 · 2 studies on file

Reported associations

  • A multi-ancestry genome-wide association study in type 1 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 38453145

    ABSTRACT: Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of the pancreatic β-cells. Genome-wide association (GWAS) and fine mapping studies have been conducted mainly in European ancestry (EUR) populations. We performed a multi-ancestry GWAS to identify SNPs and HLA alleles associated with T1D risk and age at onset. EUR families (N = 3223), and unrelated individuals of African (AFR, N = 891) and admixed (Hispanic/Latino) ancestry (AMR, N = 308) were genotyped using the Illumina HumanCoreExome BeadArray, with imputation to the TOPMed reference panel. The Multi-Ethnic HLA reference panel was utilized to impute HLA alleles and amino acid residues. Logistic mixed models (T1D risk) and frailty models (age at onset) were used for analysis. In GWAS meta

  • Candidate loci shared among periodontal disease, diabetes and bone density - Unknown journal (n.d.) · Unknown authors · PubMed 36778599

    ABSTRACT: Introduction While periodontal disease (PD) has been associated with type 2 diabetes (T2D) and osteoporosis, the underlying genetic mechanisms for these associations remain largely unknown. The aim of this study is to apply cross-trait genetic analyses to investigate the potentially shared biology among PD, T2D, and bone mineral density (BMD) by assessing pairwise genetic correlations and searching for shared polymorphisms. Methods We applied cross-trait genetic analyses leveraging genome-wide association study (GWAS) summary statistics for: Periodontitis/loose teeth from the UKBB/GLIDE consortium (PerioLT, N=506594), T2D from the DIAGRAM consortium (Neff=228825), and BMD from the GEFOS consortium (N=426824). Among all three, pair-wise genetic correlations were estimated with lin

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • type 2 diabetes screening and monitoring Moderate

    C-allele carriers have increased genetic risk for type 2 diabetes based on genome-wide association; personalized screening may enable early intervention.

    Discuss earlier HbA1c and glucose testing and screening intervals based on genetic and clinical risk factors.