rs10769936 - TRIM66
Magnitude 2.2 · 2 studies on file
Reported associations
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation - Unknown journal (n.d.) · Unknown authors · PubMed 35551307
ABSTRACT: We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent) through the DIAMANTE (DIAbetes Meta-ANalysis of Trans-Ethnic association studies) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10−9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular me
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Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925
ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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HbA1c and fasting glucose High
Increased genetic risk for Type 2 diabetes warrants proactive glucose metabolism monitoring to detect dysglycemia early
Annual testing; consider 6-month intervals if prediabetes signs emerge
Discuss with your doctor
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Personalized Type 2 diabetes prevention strategy High
Genetic risk assessment combined with lifestyle counseling is the evidence-based approach to diabetes prevention in high-risk individuals
Screening
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Type 2 diabetes screening High
rs10769936 risk allele (C) is associated with increased Type 2 diabetes risk in large GWAS studies, likely through effects on TRIM66 expression in metabolic tissues
Consider screening from age 30 or earlier; discuss interval with healthcare provider