Expressive

rs10766994 - CCDC179 - LINC02718

Magnitude 2.2 · 1 study on file

Reported associations

  • Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke - Unknown journal (n.d.) · Unknown authors · PubMed 36240095

    ABSTRACT: Background and Objectives Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. Methods We performed a meta-analysis of genome-wide association studies of early-onset stroke (EOS), ages 18-59 years, using individual-level data or summary statistics in 16,730 cases and 599,237 nonstroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late-onset stroke (LOS) and compared polygenic risk scores (PRS) for venous thromboembolism (VTE) between EOS and LOS. Results We observed genome-wide significant associations of EOS with 2 varia

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • blood pressure control Moderate

    hypertension is a major modifiable stroke risk factor; early detection and management reduces risk

    home or clinical blood pressure monitoring; target systolic less than 130 mmHg per guidelines

Diet

  • heart-protective diet: DASH or Mediterranean pattern Moderate

    reduces blood pressure and systemic inflammation, mitigating stroke risk in genetically predisposed individuals

    emphasize whole grains, vegetables, fruits, fish, olive oil; limit sodium below 2300mg daily

Discuss with your doctor

  • personalized stroke prevention plan Moderate

    genetic predisposition to early-onset stroke warrants evaluation for lifestyle and pharmacologic prevention strategies

    discuss genetic variant with physician; review preventive interventions

Exercise

  • regular cardiovascular exercise program Moderate

    improves endothelial function and reduces vascular inflammation; addresses key mechanisms underlying stroke risk

    minimum 150 minutes moderate intensity aerobic activity weekly

Screening

  • comprehensive cardiovascular risk assessment Moderate

    rs10766994 is associated with increased early-onset ischemic stroke risk; baseline and ongoing evaluation identifies modifiable risk factors

    baseline cardiovascular evaluation by age 25-30; annual monitoring thereafter