rs10766075 - BMAL1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life - Unknown journal (n.d.) · Unknown authors · PubMed 30867560
ABSTRACT: Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is made up of multiple heterogeneous facets, each contributing to the effect of neuroticism as a whole. A recent study showed that a 12-item neuroticism scale described one broad trait of general neuroticism and two special factors, one characterizing the extent to which people worry and feel vulnerable, and the other characterizing the extent to which people are anxious and tense. This study also found that, although individuals who were higher on general neuroticism li
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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consistent sleep schedule and circadian rhythm stability Moderate
BMAL1 regulates circadian clock and is expressed in brain regions controlling emotional processing; circadian stability supports anxiety management
maintain regular sleep-wake schedule; aim for 7-9 hours per night
Screening
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mental health assessment for worry and anxiety Moderate
BMAL1 variant associated with increased worry vulnerability and neuroticism in large GWAS; may indicate elevated baseline anxiety risk
annual mental health screening; discuss with healthcare provider if symptoms present