rs1076540 - MICAL3
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma - Unknown journal (n.d.) · Unknown authors · PubMed 22001757
ABSTRACT: Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation an
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Monitor liver function with periodic bloodwork Moderate
Elevated GGT is a risk marker for cirrhosis, hepatocellular carcinoma, type 2 diabetes, and cardiovascular disease.
Annual liver enzyme tests (GGT, ALT, ALP)
Lifestyle
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Limit alcohol consumption Moderate
This variant increases baseline GGT levels; GGT is particularly sensitive to alcohol, and elevated GGT is associated with liver injury and disease risk.
Limit alcohol to no more than 1-2 drinks per week
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Maintain healthy body weight Moderate
Obesity is associated with elevated liver enzymes and GGT; this variant predisposes to higher baseline GGT.
Target BMI 18.5-24.9; discuss weight management goals with provider