rs10764326 - CACNB2
Magnitude 2.2 · 1 study on file
Reported associations
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A scalable variational inference approach for increased mixed-model association power - Unknown journal (n.d.) · Unknown authors · PubMed 39789286
ABSTRACT: The rapid growth of modern biobanks is creating new opportunities for large-scale genome-wide association studies (GWASs) and the analysis of complex traits. However, performing GWASs on millions of samples often leads to trade-offs between computational efficiency and statistical power, reducing the benefits of large-scale data collection efforts. We developed Quickdraws, a method that increases association power in quantitative and binary traits without sacrificing computational efficiency, leveraging a spike-and-slab prior on variant effects, stochastic variational inference and graphics processing unit acceleration. We applied Quickdraws to 79 quantitative and 50 binary traits in 405,088 UK Biobank samples, identifying 4.97% and 3.25% more associations than REGENIE and 22.71%
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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CACNB2 variant and hypertension risk Moderate
Large-scale GWAS identifies this locus as significantly associated with hypertension risk
Lifestyle
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cardiovascular health optimization Moderate
Variants in CACNB2 affect blood pressure regulation; lifestyle factors substantially modify hypertension risk
aerobic exercise 150 min/week, DASH diet, stress management
Screening
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blood pressure Moderate
CACNB2 encodes a calcium channel subunit regulating vascular tone; the variant associates with elevated blood pressure
baseline measurement, then annual screening