rs10761745 - JMJD1C
Magnitude 2.8 · 1 study on file
Reported associations
-
Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 28406950
ABSTRACT: The objective of this study is to find single nucleotide polymorphisms (SNPs) associated with a risk of Type 2 diabetes (T2D) in Korean adults and to investigate the longitudinal association between these SNPs and T2D and the interaction effects of iron intake and average hemoglobin level. Data from the KoGES_Ansan and Ansung Study were used. Gene-iron interaction analysis was conducted using a two-step approach. To select candidate SNPs associated with T2D, a total of 7,935 adults at baseline were included in genome-wide association analysis (step one). After excluding T2D prevalent cases, prospective analyses were conducted with 7,024 adults aged 40-69 (step two). The association of selected SNPs and iron status with T2D and their interaction were determined using a Cox propo
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
Hemoglobin levels in women Moderate
rs10761745 interacts with hemoglobin level on T2D risk in women (P=0.0077); elevated hemoglobin was independently associated with T2D
Annual hemoglobin testing; iron panel if elevated
Diet
-
Dietary iron intake Moderate
Iron intake was prospectively associated with T2D; the JMJD1C variant affects iron absorption through androgen-hepcidin signaling pathways
Track dietary iron intake; maintain recommended range (8-18 mg/day)
Screening
-
Type 2 diabetes risk screening Moderate
rs10761745 shows prospective association with T2D risk; C allele carriers have elevated baseline diabetes risk
Annual fasting glucose and HbA1c testing