Expressive

rs10761240 - PHF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. - Nature genetics (2019) · Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D · PubMed 30804565

    Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. Here, we use a large genetic association sample (n = 1,331,010) to detect novel loci and gain insight into the pathways, tissue and cell types involved in insomnia complaints. We identify 202 loci implicating 956 genes through positional, expression quantitative trait loci, and chromatin mapping. The meta-analysis explained 2.6% of the variance. We show gene set enrichments for the axonal part of neurons, cortical and subcortical tissues, and specific cell types, including striatal, hypothalamic, and claustrum neurons. We found considerable genetic correlations with psychiatric tr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to insomnia and prevention strategies Moderate

    Carrying rs10761240-G increases insomnia risk; physician can tailor screening and management

    Discuss sleep quality, sleep difficulties, and daytime impairment at next appointment

Lifestyle

  • Sleep hygiene optimization Moderate

    Consistent sleep habits and sleep environment optimization may help mitigate genetic insomnia risk

    Maintain consistent sleep schedule, keep bedroom dark and cool, limit screens 1 hour before bed

Screening

  • Sleep quality and insomnia symptoms Moderate

    rs10761240-G allele increases genetic susceptibility to insomnia with significant effect size

    Track sleep quality, sleep duration, and daytime functioning; report concerns to physician