rs10760123 - PHF19
Magnitude 2.2 · 1 study on file
Reported associations
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Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology - Unknown journal (n.d.) · Unknown authors · PubMed 29083406
ABSTRACT: Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS, n=360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P<3x10-8), including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology. Disease-specific effects were detected for only six variants, confirming that most represent shared risk factors. Tissue-specific heritability and biological process enrichment analyses suggest that shared risk variants influence lymphocyte-mediated immunity. Six target
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized allergic disease risk and screening strategy Moderate
GWAS meta-analysis of 360,838 individuals confirms association between rs10760123 and allergic diseases
review genetic risk assessment and establish screening protocol
Screening
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baseline allergy testing and IgE screening Moderate
Genetic variant increases allergic disease risk via CUTALP expression changes in immune and respiratory tissues
skin prick test or serum-specific IgE panel at baseline